The use of cannabis for pain management: Potential side effects on myofascial tissues of the musculoskeletal system.

The use of cannabis for pain management: Potential side effects on myofascial tissues of the musculoskeletal system. 06/11/2022

Sensitivity of the Fasciae to the Endocannabinoid System: Production of Hyaluronan-Rich Vesicles and Potential Peripheral Effects of Cannabinoids in Fascial Tissue

In Summary

Myofascial tissue is a thin, strong, fibrous connective tissue that extends throughout the body to provide support and protection to muscles and bones. Myofascial pain is a common clinical disorder, in which patients feel acute muscle pain and weakness, and experience decreased range of motions. This disorder affects 85% of the population at least once during their lifetimes.

In the US, over the past decade, the availability and usage of cannabis in medical context has consistently increased, and myofascial pain has been one of the conditions reported to be alleviated by cannabis therapy.

However, a recent study has demonstrated that cannabinoids - the major biologically active components of cannabis - affect the function of the fasciae, a constituent of the myofascial tissue. In particular, the fasciae helps synthesize the extracellular matrix (EM), a three-dimensional network of extracellular molecules that provide structural and biochemical support to surrounding cells in the myofascial tissue. Exposure to cannabinoids alter the biosynthesis of the EM by the fasciae and consequently remodels all surrounding cells and tissues. This finding suggests that therapeutic applications of cannabinoids to treat pain may lead to unwanted side effects to our musculoskeletal system.

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CED Clinic blogs are authored by a collaborative team of diverse and accomplished authors, each bringing a unique perspective and set of skills to our blog. Comprised of individuals with backgrounds in Psychology, Medicine, and Research, our multifaceted team is dedicated to producing high-quality content that explores the intersection of science, news, and wellness. Our commitment to staying up-to-date on the latest research and trends in the field ensures that the writing we share is both informative and relevant. We strive to share a holistic approach to health and wellbeing, and to empower readers to take control of their mental health and live their best lives.

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